Justice League America Movie
Villains
Max Lord
Initially, Lord worked behind the scenes to establish the League, while under the control of a villainous computer created by Metron (a later retcon would say that this was actually the villainous computer program Kilgore, which had taken over Metron's machine). The computer wanted Max to set up a worldwide peacekeeping organization, as part of its plan to dominate the world.
ONACs
Although OMACs are now cyborgs who take over human bodies via a virus (created from Brainiac-13-derived nanotechnology acquired by the U.S. Department of Defense and Lexcorp, which was then secretly introduced into general vaccine supplies) in order to assassinate any and all beings with superpowers, they still retain OMAC's familiar crest and Brother Eye symbol on their chest. The OMACs are featured in the OMAC Project mini-series that leads up to Infinite Crisis.